Pramiracetam was made of Piracetam by Parke-Davis and replaced the amide group with a group of dipropano-2-ylaminoethyl around 1970. Parke-Davis was formerly the largest and oldest medicine manufacturer in America. It was purchased by Pfizer in 2000 as part of its Warner-Lambert transaction. The prescription medication Pramiracetam is legalized and is sold as a Pramistar, Neupramir or Remen in different parts of the world. Pramiracetam in the United States is offered to the nootropic community as an OTC ‘research substance ‘Pramiracetam increases your brain’s nitric oxide activity. Contribute to enhancing the circulation of brain cells, which enhances the effectiveness of brain motor, learning and visual function.